Painkillers and hormonal contraception have been linked to a raised blood clot risk.

A recent Danish study published in The BMJ has discovered a modestly increased risk of venous thromboembolism (VTE), commonly known as blood clots, in women who use non-steroidal anti-inflammatory drugs (NSAIDs) alongside hormonal contraception.

The research, based on the medical records of two million women aged 15 to 49 over a decade, shows that the risk of VTE is higher for women using combined oral contraceptives containing third or fourth-generation progestins when taking NSAIDs like ibuprofen, diclofenac, and naproxen. 

Progestin-only methods such as tablets, implants, and coils carry a lower risk when used with these painkillers.

While the absolute risk remains low, the study found up to 23 extra VTE events per week per 100,000 women using high-risk hormonal contraception and NSAIDs. 

Among NSAIDs, diclofenac demonstrated the strongest association with blood clots.

However, the study is observational and cannot establish causation. 

Crucial factors like smoking and obesity were not addressed. The researchers recommend advising women on the potential interaction between hormonal contraception and NSAIDs.

The experts say the findings highlight the importance of considering alternative pain relief options and lower-risk contraceptives when appropriate.